Recent publications:
- DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
Göder A, Maric CA, Rainey MD, O’Connor A, Cazzaniga C, Shamavu D, Cadoret JC, Santocanale C.
J Cell Biol. 2024 Aug 5;223(8):e202402144. doi: 10.1083/jcb.202402144. Epub 2024 Jun 12.
PMID: 38865090 Free PMC article.
- CDC7 inhibition drives an inflammatory response and a p53-dependent senescent-like state in breast epithelial cells.
Cazzaniga C, Göder A, Rainey MD, Quinlan A, Coughlan S, Bernard S, Santocanale C.
FEBS J. 2024 Mar 31. doi: 10.1111/febs.17127. Online ahead of print.
PMID: 38555567
- PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors.
Göder A, Quinlan A, Rainey MD, Bennett D, Shamavu D, Corso J, Santocanale C.
iScience. 2023 May 26;26(6):106951. doi: 10.1016/j.isci.2023.106951. eCollection 2023 Jun 16.
PMID: 37378325 Free PMC article.
- ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.
Rainey MD, Bennett D, O’Dea R, Zanchetta ME, Voisin M, Seoighe C, Santocanale C.
Cell Rep. 2020 Sep 1;32(9):108096. doi: 10.1016/j.celrep.2020.108096.
PMID: 32877678 Free article.
- CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage.
Rainey MD, Quinlan A, Cazzaniga C, Mijic S, Martella O, Krietsch J, Göder A, Lopes M, Santocanale C.
EMBO Rep. 2020 Aug 5;21(8):e48920. doi: 10.15252/embr.201948920. Epub 2020 Jun 4.
PMID: 32496651 Free PMC article.
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