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# santocanalelab.net

## Sitemaps

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## Pages

- [Home](https://santocanalelab.net/) - we like to Research Dissect the mechanisms of genome duplication by using a wide range of classical and modern technologies. Develop Develop the next generation of researchers by comprehensive training an collaborative research. Experience Enjoy life in Galway, the most vibrant and inclusive city in Ireland, and in its beautiful surroundings how we work In
- [People](https://santocanalelab.net/people/) - Our current team members Meet our team and alumni Join us now! Prof. Corrado Santocanale Principal Investigator Corrado Santocanale received his Ph.D. in Cellular and Molecular Biology from the University of Milan, Italy under the co-supervision of Paolo Plevani and Giovanna Lucchini. As a postdoctoral fellow at the Imperial Cancer Research Fund (now Cancer Research
- [Contact us](https://santocanalelab.net/contact-us/) - We are happy to consider new lab members at all levels: email corrado.santocanale@universityofgalway.ie for details. Centre for Chromosome BiologySchool of Biological and Chemical SciencesUniversity of GalwayGalway H91 W2TYIreland Our University Pics from Galway All pictures were a kind gift from our colleague Professor Chaosheng Zhang. More of his work here
- [Publications](https://santocanalelab.net/publications/) - Recent publications: DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.Göder A, Maric CA, Rainey MD, O'Connor A, Cazzaniga C, Shamavu D, Cadoret JC, Santocanale C.J Cell Biol. 2024 Aug 5;223(8):e202402144. doi: 10.1083/jcb.202402144. Epub 2024 Jun 12.PMID: 38865090 Free PMC article. CDC7 inhibition drives an inflammatory response and a p53-dependent senescent-like
- [Research](https://santocanalelab.net/research/) - Our research: This video shows the first line of cellular response to replication stress induced by CDC7 inhibition which is dependent on ETAA1 and ATR. Consequences of CDC7 inhibition: Drugs that block DNA replication prevent cell proliferation, which may result in anticancer activity. The latter is dependent on the drug's mode of action as well
- [prova](https://santocanalelab.net/prova/) - Unraveling DNA Replication Mysteries Discovering the Secrets of Life Explore Now! 100+ Unlocking DNA secrets for you 360+ Comprehensive molecular insights await. 24/7 Dedicated global research community. Our Research Focus DNA Replication Genomic Stability Cellular Responses Our Mission We are a dynamic research group dedicated to unraveling the intricate molecular mechanisms of DNA replication in