Selected Recent Publications

  • Göder A, Quinlan A, et al PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors -PREPRINT DOI10.2139/ssrn.4344116 SSRN ID4344116
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  • Rainey MD, Bennett D, O'Dea R, et al. ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition. Cell Rep. 2020;32(9):108096. doi:10.1016/j.celrep.2020.108096
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  • CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage. Rainey MD, Quinlan A, Cazzaniga C, Mijic S, Martella O, Krietsch J, Göder A, Lopes M, Santocanale C. EMBO Rep. 2020 Jun 4:e48920. doi: 10.15252/embr.201948920. Online ahead of print. PMID: 32496651
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  • O'Dea R, and Santocanale C. Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase. Journal of Cell Science (2020) 133: jcs233437 doi: 10.1242/jcs.233437 PMID: 31964704
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  • Rainey MD, Quachthithu H, Gaboriau D, Santocanale C. DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors. ACS Chem Biol. (2017) Jul 21;12(7):1893-1902. PMID: 28560864.
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  • DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach. Wu KZ, Wang GN, Fitzgerald J, Quachthithu H, Rainey MD, Cattaneo A, Bachi A, Santocanale C. Nucleic Acids Res. 2016 Oct 14;44(18):8786-8798. doi: 10.1093/nar/gkw626. Epub 2016 Jul 12. PMID: 27407105
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  • The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase. McGarry E, Gaboriau D, Rainey MD, Restuccia U, Bachi A, Santocanale C. Cancer Res. 2016 Apr 15;76(8):2384-93. doi: 10.1158/0008-5472.CAN-15-2890. Epub 2016 Feb 26. PMID: 26921344
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  • Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint. O'Connor A, Maffini S, Rainey MD, Kaczmarczyk A, Gaboriau D, Musacchio A, Santocanale C. Biol Open. 2015 Dec 18;5(1):11-9. doi: 10.1242/bio.014969. PMID: 26685311
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  • Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint. Rainey MD, Harhen B, Wang GN, Murphy PV, Santocanale C. Cell Cycle. 2013 May 15;12(10):1560-8. doi: 10.4161/cc.24675. Epub 2013 Apr 17. PMID: 23598722
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  • Kliszczak AE, Rainey MD, Harhen B, Boisvert FM, Santocanale C. DNA mediated chromatin pull-down for the study of chromatin replication. Sci Rep. (2011);1:95. doi: 10.1038/srep00095. PMID: 22355613
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Selected Early Publications

  • A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Montagnoli A, Valsasina B, Croci V, Menichincheri M, Rainoldi S, Marchesi V, Tibolla M, Tenca P, Brotherton D, Albanese C, Patton V, Alzani R, Ciavolella A, Sola F, Molinari A, Volpi D, Avanzi N, Fiorentini F, Cattoni M, Healy S, Ballinari D, Pesenti E, Isacchi A, Moll J, Bensimon A, Vanotti E, Santocanale C. Nat Chem Biol. 2008 Jun;4(6):357-65. doi: 10.1038/nchembio.90. Epub 2008 May 11. PMID: 18469809
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  • Cdc7 is an active kinase in human cancer cells undergoing replication stress. Tenca P, Brotherton D, Montagnoli A, Rainoldi S, Albanese C, Santocanale C. J Biol Chem. 2007 Jan 5;282(1):208-15. doi: 10.1074/jbc.M604457200. Epub 2006 Oct 24. PMID: 17062569
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  • Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases. Montagnoli A, Valsasina B, Brotherton D, Troiani S, Rainoldi S, Tenca P, Molinari A, Santocanale C. J Biol Chem. 2006 Apr 14;281(15):10281-90. doi: 10.1074/jbc.M512921200. Epub 2006 Jan 30. PMID: 16446360
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  • Drf1, a novel regulatory subunit for human Cdc7 kinase. Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C. EMBO J. 2002 Jun 17;21(12):3171-81. doi: 10.1093/emboj/cdf290. PMID: 12065429
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  • Activation of dormant origins of DNA replication in budding yeast. Santocanale C, Sharma K, Diffley JF. Genes Dev. 1999 Sep 15;13(18):2360-4. doi: 10.1101/gad.13.18.2360. PMID: 10500092
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  • A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Santocanale C, Diffley JF. Nature. 1998 Oct 8;395(6702):615-8. doi: 10.1038/27001. PMID: 9783589
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Journal covers featuring our work